Compared to other risk equations, the Framingham risk equations have favorable characteristics: they were developed in a large prospective cohort of U.S. These equations calculate the absolute risk of CHD events for patients with no known previous history of CHD, stroke, or peripheral vascular disease (primary prevention). Among the various risk prediction equations, those derived from the Framingham Heart Study are most commonly recommended for use in the United States. Some of the available risk equations, however, have limitations: they include relatively few risk factors are derived from truncated middle-aged or male-only populations use logistic regression models that require fixed follow-up periods (e.g., 10 years) treat events occurring at 1 year the same as events occurring at 5 or 10 years and have been prospectively validated in limited populations.
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